丁苯那嗪和α-甲基间酪氨酸对大鼠探索活动及脑儿茶酚胺的影响。
Effect of tetrabenazine and alpha-methyl-m-tyrosine on exploratory activity and brain catecholamines in rats.
作者信息
Chan O L, Webster R A
出版信息
Br J Pharmacol. 1971 Apr;41(4):691-9. doi: 10.1111/j.1476-5381.1971.tb07077.x.
Abstract
- Spontaneous exploratory locomotor activity of Wistar rats was measured in photocell activity cages, and brain noradrenaline (NA) and dopamine (DA) were determined fluorometrically after ion exchange purification.2. Tetrabenazine (TBZ) (10 mg/kg) produced a fall in NA and DA concentrations in rat brain stems which was correlated with the fall in activity in female Wistar rats.3. alpha-Methyl-m-tyrosine (alphaMMT) reduced the concentration of rat brain NA without affecting DA concentration or activity.4. Pretreatment with alphaMMT did not stop TBZ from producing a marked reduction in activity and NA concentration, but partially protected DA from the depleting action of TBZ.5. These results support a role for catecholamines in the control of motor activity, but they do not implicate NA more than DA and they emphasize that the mechanism by which drugs affect the concentrations of catecholamines may be more important than the gross concentrations attained.
摘要
在光电管活动笼中测量Wistar大鼠的自发探索性运动活动，并在离子交换纯化后用荧光法测定脑去甲肾上腺素（NA）和多巴胺（DA）。
丁苯那嗪（TBZ）（10毫克/千克）使大鼠脑干中NA和DA浓度下降，这与雌性Wistar大鼠活动的下降相关。
α-甲基间酪氨酸（αMMT）降低大鼠脑NA浓度，而不影响DA浓度或活动。
用αMMT预处理并未阻止TBZ使活动和NA浓度显著降低，但部分保护DA免受TBZ的耗竭作用。
这些结果支持儿茶酚胺在运动活动控制中的作用，但它们并未表明NA比DA更重要，并且它们强调药物影响儿茶酚胺浓度的机制可能比所达到的总浓度更重要。
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