啮齿动物饮食混合物中各种药物的测定。

Determination of various drugs in rodent diet mixtures.

作者信息

Hucker H B, Stauffer S C

出版信息

J Chromatogr. 1977 Jan 21;131:357-63. doi: 10.1016/s0021-9673(00)80952-8.

Abstract

Methods employing solvent extraction, thin-layer chromatography, gas-liquid chromatography, and UV spectrophotometry are described for the quantitative determination of halofenate, cyclobenzaprine and sulindac in rodent diet mixtures. Halofenate was hydrolyzed to its free acid derivative and converted to a methyl ester prior to assay. The drugs were shown to be stable when stored in food mixtures at room temperature for seven days. Diet mixtures containing the three drugs were demonstrated to be uniformly mixed by the procedure employed.

摘要

描述了采用溶剂萃取、薄层色谱法、气液色谱法和紫外分光光度法对啮齿动物饮食混合物中的卤芬酯、环苯扎林和舒林酸进行定量测定的方法。在测定之前，卤芬酯被水解为其游离酸衍生物并转化为甲酯。结果表明，这些药物在室温下储存在食物混合物中7天是稳定的。通过所采用的程序证明，含有这三种药物的饮食混合物混合均匀。