Fernie D S, Ware D A, Park R W
J Med Microbiol. 1977 May;10(2):233-40. doi: 10.1099/00222615-10-2-233.
Dimetridazole, a nitroimidazole drug reported to act only on obligately anaerobic micro-organisms, is widely used for the prevention and treatment of swine dysentery. Forty-four strains of the microaerophilic bacterium Campylobacter coli isolated from either healthy or diseased pigs, and a strain of Campylobacter fetus, were all sensitive to dimetridazole. The sensitivities (minimal inhibitory concentration less than 10 microng per ml) were similar to those of anaerobic bacteria. Dimetridazole inhibited growth of campylobacters in a shaken culture in air, but did not inhibit uptake of oxygen. Inhibition of growth appeared to result from an inhibition of nucleic-acid synthesis and does not seem to depend upon interference with electron transport in the catabolism of pyruvate.
二甲硝唑是一种据报道仅作用于专性厌氧微生物的硝基咪唑类药物，广泛用于预防和治疗猪痢疾。从健康或患病猪中分离出的44株微需氧的大肠弯曲菌菌株以及1株胎儿弯曲菌菌株，均对二甲硝唑敏感。其敏感性（最低抑菌浓度低于每毫升10微克）与厌氧菌相似。二甲硝唑在空气中的振荡培养物中可抑制弯曲菌的生长，但不抑制氧气的摄取。生长抑制似乎是由于核酸合成受到抑制，且似乎不依赖于对丙酮酸分解代谢中电子传递的干扰。
