“厌食性”药物是通过抑制食欲来实现体重减轻的吗？

Do "anorectic" drugs produce weight loss by appetite suppression?

作者信息

Kirby M J, Turner P

出版信息

Lancet. 1976 Mar 13;1(7959):566-7. doi: 10.1016/s0140-6736(76)90360-3.

Abstract

A peripheral action on glucose metabolism may play an improtant part in the weight loss associated with treatment with some antiobesity drugs such as fenfluramine and mazindol. In therapeutic concentrations these agents increase glucose uptake into animal and human skeletal muscle. This action is distinct from their effects on central transmitters and from the reduction in food intake in animals.

摘要

某些抗肥胖药物（如芬氟拉明和马吲哚）治疗相关的体重减轻中，对葡萄糖代谢的外周作用可能起重要作用。在治疗浓度下，这些药物可增加动物和人类骨骼肌对葡萄糖的摄取。这种作用不同于它们对中枢递质的影响以及对动物食物摄入量的减少。