Lawrence J S
Clin Exp Immunol. 1967 Dec;2(Suppl):Suppl:769-83.
Rheumatoid serum factors are present in greater or lesser concentration in 10–40% of individuals, the titre distribution varying in different populations and being higher, as a rule, in the older age groups. Concordance between different serum factors occurs more often than would be expected by chance, and individuals with more than one factor or with a high titre of a single factor are more likely to have rheumatoid arthritis (RA). Rheumatoid serum factors are found more often in the offspring of seropositive individuals than in persons of the same age distribution in the remainder of the population. Rheumatoid arthritis is aggregated in families independently of the rheumatoid serum factors. The aggregation is only of the severe grades with marked erosion of cartilage and bone. It is suggested that rheumatoid serum factors may be produced by a number of different antigens and that a summation of the effect of several antigens may be important. Evidence is produced suggesting that rheumatoid arthritis may be triggered by some common respiratory infections. The more severe forms, however, appear to depend on a predisposition which may be genetically determined.
类风湿血清因子在10% - 40%的个体中或多或少都有一定浓度存在，其滴度分布在不同人群中有所不同，通常在老年人群体中更高。不同血清因子之间的一致性比偶然预期的更为常见，具有多种因子或单一因子高滴度的个体更有可能患类风湿关节炎（RA）。与其余人群中相同年龄分布的人相比，类风湿血清因子在血清阳性个体的后代中更常见。类风湿关节炎在家族中聚集，与类风湿血清因子无关。这种聚集仅见于伴有明显软骨和骨侵蚀的严重等级病例。有人提出，类风湿血清因子可能由多种不同抗原产生，几种抗原作用的总和可能很重要。有证据表明，类风湿关节炎可能由一些常见的呼吸道感染引发。然而，更严重的形式似乎取决于一种可能由基因决定的易感性。
