Hollander W F, Waggie K S
J Hered. 1977 Jan-Feb;68(1):41-7. doi: 10.1093/oxfordjournals.jhered.a108770.
A semisterile F1 male mouse from an X-ray experiment produced about 25 percent lethal gnome young in outcrosses. These animals were about half normal size, with short tail and small eyes, and died at birth. Surviving progeny were of four classes: 1) like the sire, 2) semisterile, 3) normal, and 4) gnome-producing, but not semisterile. Two independent reciprocal translocations have been identified from the original male, one of the classic type giving semisterile heterozygotes and involving chromosomes 5 and 15. The second translocation seems to be very small, giving the gnome type as one duplication-deficiency product, and the other unbalanced type seeming to pass for normal, although large body size and occasional agnathism may be produced. The small translocation has been found linked with the loci of v (waltzing) and Sl (steel) on chromosome 10. Cytological study has not revealed obvious structural changes. The translocation is now maintained in the homozygous state. The designation T(10;?)2Ho is proposed.
在一项X射线实验中，一只半不育的F1雄性小鼠在杂交后代中产生了约25%的致死侏儒幼崽。这些动物体型约为正常大小的一半，尾巴短，眼睛小，出生时即死亡。存活的后代有四类：1）像父本；2）半不育；3）正常；4）产生侏儒，但不是半不育。从最初的雄性小鼠中鉴定出了两个独立的相互易位，其中一个是经典类型，产生半不育杂合子，涉及5号和15号染色体。第二个易位似乎非常小，其一个重复-缺失产物为侏儒类型，另一个不平衡类型看似正常，尽管可能会产生大体型和偶尔的无颌畸形。已发现这个小易位与10号染色体上的v（摇摆）和Sl（钢铁）基因座连锁。细胞学研究未发现明显的结构变化。该易位现在保持纯合状态。建议命名为T(10;?)2Ho。
