溶液中抗组胺药和抗高血压药的构象群体。
Conformational populations for antihistamines and antihypertensives in solution.
作者信息
Ham N S
出版信息
J Pharm Sci. 1976 Apr;65(4):612-4. doi: 10.1002/jps.2600650437.
PMID:5591
Abstract
The conformations in aqueous solution were determined for the XCH2CH2N systems of some antihistamines (H1-receptor antagonists) and some adrenergic neuron blocking agents, including the antihypertensive drugs guanethidine and guanoclor. The rotameric species thought to be the pharmacologically active one is often not the only rotamer present in solution.
摘要
测定了一些抗组胺药（H1受体拮抗剂）和一些肾上腺素能神经阻断剂的XCH2CH2N体系在水溶液中的构象，其中包括抗高血压药物胍乙啶和胍氯。被认为具有药理活性的旋转异构体往往不是溶液中唯一存在的旋转异构体。
Zotero 插件