Prelinimary report on combination therapy for advanced prostatic cancer.

Fifteen patients with carcinoma of the prostate (ten, stage D; three, stage C; and two, stage B) were treated with the combination of radical retropubic prostatectomy, bilateral orchiectomy, estrogen therapy, and chemotherapy with 5-fluorouracil and cyclophosphamide. Fourteen patients have been clinically free of disease from 2 to 20 months. One patient died free of disease from myocardial infarction in the post-operative period. Lymphangiography was accurate in 14 of the 15 patients. Acid phosphatase levels in serum did not reflect with precision the extension of the tumor in seven of ten patients with stage D disease. The rationale of this therapeutic approach is discussed.