Hayashi S, Kawano H
Endocrinol Jpn. 1977 Apr;24(2):179-84. doi: 10.1507/endocrj1954.24.179.
Electrolytic lesions were placed in the hypothalamus of two-day-old female rats. Destruction of the mediobasal part of the preoptic area resulted in persistent vaginal estrus starting on the day of vaginal opening, while lesions placed laterally in the preoptic-anterior hypothalamic area did not interfere with normal cycles. Therefore, the mediobasal hypothalamus is capable of undergoing maturation without any postnatal influence from at least the mediobasal part of the anterior hypothalamus. Destruction of the anterior wall of the third ventricle also caused persistent or prolonged vaginal estrus preceded by normal cycles. The relationship between the loci of lesions and the occurrence of sexual cyclicity was discussed.
对两日龄雌性大鼠的下丘脑进行电解损伤。视前区内侧基部的破坏导致从阴道开口之日起出现持续的阴道发情，而在视前 - 下丘脑前部区域外侧进行的损伤并不干扰正常的周期。因此，下丘脑内侧基部能够在没有来自至少下丘脑前部内侧基部的任何产后影响的情况下成熟。第三脑室前壁的破坏也导致在正常周期之前出现持续或延长的阴道发情。讨论了损伤部位与性周期发生之间的关系。
