Lydiard R B, Sparber S B
Dev Psychobiol. 1977 Jul;10(4):305-14. doi: 10.1002/dev.420100404.
We have previously reported that injection of dl-alphamethylparatyrosine methylester (AMPT) into the yolk sac of fertilized chicken eggs prior to incubation results in dose-related increases in the specific activity of tyrosine hydroxylase (TH) at 29 days postnatally. We now report that injection of 10.0 and 33.3 mg/kg of AMPT prior to incubation results in dose-related increases in acquisition rates of 2 operant responses. Between 1 and 3 weeks of postnatal age, we observed a dose-related decrease in latency to perform a detour response and, at 55-60 days of postnatal age, an increased rate of acquisition of a key peck response in an autoshaping paradigm. We could not discern any significant alteration in several measures of unconditioned behaviors in an open field situation at 3 weeks of postnatal age. Our data support the contention that early catecholamine (CA) depletion can produce long-term alterations in postnatal behavior.
我们之前曾报道，在孵化前向受精鸡蛋的卵黄囊中注射dl-α-甲基对酪氨酸甲酯（AMPT），会导致出生后29天时酪氨酸羟化酶（TH）的比活性呈剂量相关增加。我们现在报道，孵化前注射10.0和33.3mg/kg的AMPT会导致两种操作性反应的习得率呈剂量相关增加。在出生后1至3周龄之间，我们观察到执行迂回反应的潜伏期呈剂量相关缩短，并且在出生后55 - 60天龄时，在自动成型范式中啄键反应的习得率增加。在出生后3周龄时，我们在旷场情境中未发现无条件行为的多项指标有任何显著改变。我们的数据支持这样的观点，即早期儿茶酚胺（CA）耗竭可导致出生后行为的长期改变。
