Nakayama S, Yamasato T, Mizutani M
Nihon Heikatsukin Gakkai Zasshi. 1977 Mar;13(1):45-53. doi: 10.1540/jsmr1965.13.45.
In anesthetized dogs, intravenous administration or intrajejunal infusion of Loperamide produced the excitatory effect of gastric, small and large bowel motilities accompanied with elevation of the muscle tone. The excitatory response was slightly suppressed by administration of atropine. Such effects were similar to those of morphine and methadone. In non-anesthetized spinal guinea pigs, Loperamide increased colonic motility accompanied with the augmentation of the colonic muscle tone, but the conduction of the contraction waves was prevented. In anesthetized guinea pigs, intravenous administration of Loperamide reduced the rate of the rhythmic contraction waves of the small intestine, but its effect on the muscle tone was not evident. The activity of Loperamide as an antidiarrheal agent was discussed.
在麻醉犬中，静脉注射或空肠内输注洛哌丁胺可产生胃、小肠和大肠运动的兴奋作用，并伴有肌张力升高。给予阿托品可轻微抑制这种兴奋反应。这些作用与吗啡和美沙酮的作用相似。在未麻醉的脊髓豚鼠中，洛哌丁胺增加结肠运动并伴有结肠肌张力增强，但收缩波的传导受阻。在麻醉豚鼠中，静脉注射洛哌丁胺可降低小肠节律性收缩波的频率，但其对肌张力的影响不明显。文中讨论了洛哌丁胺作为止泻剂的活性。
