Theodorides V J, DiCuollo C J, Nawalinski T, Miller C R, Murphy J R, Freeman J F, Killeen J C, Rapp W R
Am J Vet Res. 1977 Jun;38(6):809-14.
Acute toxicity of oxibendazole was assessed with single oral doses given to mice (4 to 32 g/kg of body weight), sheep (230 to 600 mg/kg), and cattle (600 mg/kg); there were no ill effects. Subacute toxicity did not occur with multiple doses given 5 days to cattle (30 to 75 mg/kg/day) and to sheep (10 to 50 mg/kg/day). Chronic effects did not occur with daily doses of 3 to 30 mg/kg given 98 days to rats and dogs. Teratogenicity of the compound was studied in mice, rats, and sheep medicated at a dose level of 30 mg of oxibendazole/kg and in cattle given 75 mg/kg on selected dates during pregnancy. Microscopically, rodent fetuses seemed normal, and on gross physical examination, lambs and calves were free of malformations and ossification variations.
通过对小鼠（4至32克/千克体重）、绵羊（230至600毫克/千克）和牛（600毫克/千克）单次口服给药来评估奥昔苯达唑的急性毒性；未出现不良影响。对牛（30至75毫克/千克/天）和绵羊（10至50毫克/千克/天）连续5天多次给药未出现亚急性毒性。对大鼠和狗连续98天每日给予3至30毫克/千克的剂量未出现慢性影响。在小鼠、大鼠和绵羊妊娠期间选定日期以30毫克奥昔苯达唑/千克的剂量给药，并在牛妊娠期间以75毫克/千克的剂量给药，研究了该化合物的致畸性。显微镜检查显示，啮齿动物胎儿看似正常，大体体格检查显示，羔羊和犊牛无畸形和骨化异常。
