Cole F M, Jones A W
J Clin Pathol. 1967 Jul;20(4):585-8. doi: 10.1136/jcp.20.4.585.
There have been nine cases of ;calcifying epithelial odontogenic tumour' described so far. The histological pattern is quite distinctive, and one feature is the presence of abundant intracytoplasmic and stromal material which (Vickers, Dahlin, and Gorlin, 1965) has been shown to react histochemically as amyloid. The tumour is generally believed to be epithelial in origin, arising from the reduced enamel organ of an unerupted tooth with which all the tumours so far recorded are associated. Another case is described, this time arising in the soft tissue of the lip and remote from a tooth. This tumour showed features which suggest that it is of odontoblastic origin and therefore not epithelial. Evidence is also produced to show that the ;amyloid-like' material is not degenerative but probably dentine being actively produced by the tumour cells themselves.
迄今为止，已报道了9例“牙源性钙化上皮瘤”。其组织学模式颇为独特，一个特征是存在丰富的胞浆内和间质物质，（维克斯、达林和戈林，1965年）经组织化学研究表明，该物质表现为淀粉样反应。一般认为该肿瘤起源于上皮组织，由未萌出牙的缩余釉上皮发生，迄今记录的所有肿瘤均与之相关。本文描述了另一例病例，此次发生于唇部软组织，且与牙齿无关。该肿瘤表现出的特征提示其起源于成牙本质细胞，因此并非上皮源性。同时也有证据表明，“淀粉样”物质并非退行性变产物，而可能是肿瘤细胞自身正在活跃生成的牙本质。
