Reis R L, Hannah H, Carley J E, Pugh D M
Circulation. 1977 Sep;56(3 Suppl):II128-32.
Since 1971 we have employed the Morrow procedure in 30 patients with idiopathic hypertrophic subaortic stenosis (IHSS). All manifested obstruction to left ventricular outflow either at rest or with provocation (Valsalva) and 17 had moderate or severe mitral regurgitation. There were no operative deaths. Obstruction was abolished in all patients except one in whom a trivial 15-mm pressure gradient persisted, and all patients with moderate or severe mitral regurgitation evidenced marked amelioration of the mitral regurgitation. Distinct symptomatic improvement has been experienced by all patients, and 20 are entirely asymptomatic postoperatively. No patient has experienced syncope postoperatively although 15 experienced syncope before operation. In 12 patients the electrocardiogram recorded postoperatively was essentially unchanged from the preoperative record. In 16 patients a left anterior hemiblock was apparent postoperatively. In one patient a complete left bundle branch block appeared postoperatively and one patient demonstrated Wolff-Parkinson-White syndrome. One patient died suddenly and unexpectedly 2 years following operation. This patient continued to have palpitations after operation although all other symptoms as well as the left ventricular outflow obstruction were abolished by operation. It is suggested that propranalol administration be continued postoperatively in those patients experiencing palpitations or manifesting arrhythmias. Asymmetrical septal hypertrophy dislocates the cardiac apex and papillary muscles anteriosuperiorly producing abnormal systolic anterior mitral leaflet mition. The Morrow procedure restores more normal ventricular geometry and thereby eliminates the pathophysiological mechanism of obstruction and mitral regurgitation. The myotomies and myectomy should be extended far inferior through the entire width of the septum onto the free lateral ventricular wall. The procedure can be accomplished easily and safely through a transaortic approach. Since the operative risk at present appears to be negligible, prosthetic material is not required, and the risk of significant injury to the conduction tissue is small, we feel the current status of surgery for IHSS is such that the Morrow procedure should be performed earlier in the course of patients with IHSS manifesting obstruction or mitral regurgitation.
自1971年以来,我们对30例特发性肥厚性主动脉瓣下狭窄(IHSS)患者采用了莫罗手术。所有患者在静息状态或激发试验(瓦尔萨尔瓦动作)时均表现出左心室流出道梗阻,17例患者伴有中度或重度二尖瓣反流。无手术死亡病例。除1例仍存在15毫米的轻微压力阶差外,所有患者的梗阻均被解除,所有伴有中度或重度二尖瓣反流的患者二尖瓣反流均明显改善。所有患者均有明显的症状改善,20例患者术后完全无症状。术前有15例患者发生晕厥,术后无患者发生晕厥。12例患者术后心电图与术前基本无变化。16例患者术后出现左前分支阻滞。1例患者术后出现完全性左束支阻滞,1例患者表现为预激综合征。1例患者术后2年突然意外死亡。该患者术后仍有心悸,尽管手术解除了所有其他症状及左心室流出道梗阻。建议对有心悸或心律失常的患者术后继续使用普萘洛尔。不对称性室间隔肥厚使心尖和乳头肌向前上方移位,导致二尖瓣前叶在收缩期异常运动。莫罗手术可恢复更正常的心室形态,从而消除梗阻和二尖瓣反流的病理生理机制。肌切开术和肌切除术应向下延伸至室间隔的整个宽度直至游离的心室侧壁。该手术可通过经主动脉途径轻松安全地完成。由于目前手术风险似乎可忽略不计,无需使用人工材料,且传导组织严重损伤的风险较小,我们认为IHSS的手术现状是,对于出现梗阻或二尖瓣反流的IHSS患者,应在病程早期进行莫罗手术。