Fukuda S, Tomita S, Matsuoka O
Jikken Dobutsu. 1977 Apr;26(2):103-13. doi: 10.1538/expanim1957.26.2_103.
Comparative studies are needed on the bilogical stage of the bone growth in experimental animals and human to extrapolate the data from animals to for estimating the risk of bone seeking redionuclides in man. The growth of bone length and the appearance and fusion of the secondary ossification centers of seven long bones were compared between both species. The stage of ossification was determined radiographically. The results showed that the ossifying process of the secondary ossification centers could be divided into the following three categories in mice; (1) acute ossification type, (2) remaining metastable stage type which is specific in mice and generally at the proximal end of bone, and (3) delayed ossification type. Compared with the average life span, differences in ossification between both species were that the appearance of secondary ossification centers was observed within concentrated period in mice and not in man, and that the fusion of these was observed with long duration in mice and not in man. From 17 weeks of age, the metastable status of the bone appeared in mice without complete fusion even at 27 weeks of age, for the experiment with bone seeking radionuclides, mice of age 17 weeks or more should be used consequently.
需要对实验动物和人类骨骼生长的生物学阶段进行比较研究，以便将动物数据外推至人类，从而估计亲骨性放射性核素对人类的风险。比较了两种物种的七种长骨的骨长度生长以及次级骨化中心的出现和融合情况。通过放射学方法确定骨化阶段。结果表明，小鼠次级骨化中心的骨化过程可分为以下三类：（1）急性骨化型；（2）残留亚稳阶段型，这是小鼠特有的，一般位于骨近端；（3）延迟骨化型。与平均寿命相比，两种物种骨化的差异在于，小鼠次级骨化中心在集中时间段内出现，而人类则不然，并且小鼠中这些中心的融合持续时间长，人类则不然。从17周龄开始，小鼠出现骨的亚稳状态，即使在27周龄时也未完全融合，因此对于亲骨性放射性核素实验，应使用17周龄及以上的小鼠。
