人类肾移植中的嗜异性系统。V. 嗜异性移植抗原与肠杆菌科共同抗原的关系。

A heterophile system in human renal transplantation. V. Relationship of heterophile transplantation antigen and common antigen of Enterobacteriaceae.

作者信息

McDonald J C, Jacobbi L M, Johnson E J

出版信息

Transplantation. 1976 Feb;21(2):141-8. doi: 10.1097/00007890-197602000-00009.

DOI:10.1097/00007890-197602000-00009

Abstract

Heterophile transplantation antigen and common antigen of Enterobacteriaceae appear serologically to be separate specificities. However, both antigens are common to Enterobacteriaceae, rat erythrocytes, and some human kidneys. Both antigens are obtained from various tissues by the same chemical procedure. Immunity to each antigen is frequently produced by renal transplantation. We suggest that the antigens are either separate molecules which are similar in chemical structure in the region of the antigenic determinant as well as in tissue distribution or separate reactive sites located on the same molecule. The possibility that common antigen may be a human alloantigen raises theoretical possibilities relative to susceptibility to infection and pyelonephritis, as well as to its relationship to histocompatibility.

摘要

嗜异性移植抗原和肠杆菌科共同抗原在血清学上似乎是不同的特异性。然而，这两种抗原在肠杆菌科、大鼠红细胞和一些人类肾脏中都很常见。通过相同的化学程序可从各种组织中获得这两种抗原。肾移植常常会产生针对每种抗原的免疫。我们认为，这些抗原要么是在抗原决定簇区域以及组织分布上化学结构相似的不同分子，要么是位于同一分子上的不同反应位点。共同抗原可能是一种人类同种异体抗原，这一可能性引发了与感染易感性、肾盂肾炎以及与组织相容性的关系相关的理论可能性。