Bessot J C, Vandevenne A, Petitjean R, Burghard G
Poumon Coeur. 1977;33(2):107-15.
From 8 cases of immuno-allergic accidents attributed to Rifampicine, the authors review the literature on the subject. The "flue like" syndrome is the most frequent and characteristic of those accidents, worsened by haematological and renal involvements. These accidents probably belong to a pathology of immuno-complexes in relaiton with the production of anti-Rifampicine antibodies. Among the different means of in vitro diagnosis, the test with the anti-complement antiglobulin is the most reliable, though not always in good correlation with clinical signs. Though rare and most often benign, these accidents should lead to prudence in treating recurrent tuberculosis or reusing Rifampicine after a momentary interruption.
从8例归因于利福平的免疫过敏事故中，作者回顾了该主题的文献。“流感样”综合征是这些事故中最常见且最具特征性的，血液学和肾脏受累会使其加重。这些事故可能属于与抗利福平抗体产生相关的免疫复合物病理。在不同的体外诊断方法中，抗补体抗球蛋白试验最可靠，尽管并不总是与临床症状高度相关。这些事故虽然罕见且大多为良性，但在治疗复发性结核病或在短暂中断后重新使用利福平时应谨慎。
