Napalkov N P, Tomatis L, Likhachev A Ia, Kolodin V I
Vopr Onkol. 1977;23(4):49-57.
N-nitrosoethylurea (NEU) is found to show an intensive transplacental carcinogenic effect inducing in mice different neoplasms, mainly lung adenomas. Postnatal x-ray irradiation of control animals resulted in the occurrence of ovarian tumors in some female mice. Delivary and feeding of the progeny would lead to the development of mammary gland tumors in a number of control female animals. Postnatal exposure to x-rays of mice exposed to transplacental effect of NEU resulted in the increased incidence of lung neoplasms, mainly adenocarcinomas.
已发现N-亚硝基乙基脲(NEU)具有强烈的经胎盘致癌作用,可在小鼠体内诱发不同肿瘤,主要是肺腺瘤。对对照动物进行出生后X射线照射,导致一些雌性小鼠发生卵巢肿瘤。对后代进行分娩和哺乳会导致许多对照雌性动物发生乳腺肿瘤。对受NEU经胎盘作用影响的小鼠进行出生后X射线照射,导致肺肿瘤(主要是腺癌)的发病率增加。