[羟基脲对体外培养的L5178Y成淋巴细胞中DNA片段合成和甲基化的差异性抑制作用]
[Differential inhibition of synthesis and methylation of DNA fragments by hydroxyurea in L5178Y lymphoblasts in vitro].
作者信息
Malec J, Kornacka L, Sawecka J
出版信息
Acta Haematol Pol. 1977 May-Jun;8(2):135-9.
PMID:560773
Abstract
In cultures of mouse L5178Y lymphoblasts treated with low concentrations of hydroxyurea during the logarithmic phase of growth differential inhibition of synthesis and methylation of various DNA fragments was observed. Some evidence is presented that the effect may be due to different sensitivity of cells to the action of hydroxyurea at various times of the S-phase.
摘要
在对数生长期用低浓度羟基脲处理的小鼠L5178Y淋巴母细胞培养物中，观察到各种DNA片段的合成和甲基化受到不同程度的抑制。有证据表明，这种效应可能是由于细胞在S期的不同时间对羟基脲作用的敏感性不同所致。
相似文献
1
[Differential inhibition of synthesis and methylation of DNA fragments by hydroxyurea in L5178Y lymphoblasts in vitro].[羟基脲对体外培养的L5178Y成淋巴细胞中DNA片段合成和甲基化的差异性抑制作用]
Acta Haematol Pol. 1977 May-Jun;8(2):135-9.
2
Differential cell-cycle-dependent inhibition of DNA synthesis by hydroxyurea and cytosine arabinoside in cultured L5178Y mouse lymphoma cells.羟基脲和阿糖胞苷对培养的L5178Y小鼠淋巴瘤细胞DNA合成的细胞周期依赖性差异抑制作用。
Arch Immunol Ther Exp (Warsz). 1979;27(4):539-45.
3
DNA methylation in various growth phases of cultured L5178Y murine lymphoblasts.培养的L5178Y小鼠成淋巴细胞不同生长阶段的DNA甲基化
Neoplasma. 1979;26(2):179-84.
4
L-asparaginase-induced modulation of methotrexate polyglutamylation in murine leukemia L5178Y.L-天冬酰胺酶诱导的小鼠白血病L5178Y中甲氨蝶呤多聚谷氨酰化的调节
Cancer Res. 1987 Mar 1;47(5):1313-8.
5
Morphology of lysosomes in different phases of growth of lymphoblasts of L5178Y murine leukemia.L5178Y小鼠白血病淋巴母细胞不同生长阶段溶酶体的形态学
Arch Immunol Ther Exp (Warsz). 1979;27(1-2):73-7.
6
Comparison of hydroxyurea and excess thymidine as synchronizing agents in cultures of L5178Y mouse lymphoma cells.
Folia Biol (Praha). 1977;23(4):299-304.
7
[Effect of 5-deoxy-5-S-isobutyladenosine on the synthesis and methylation of DNA in mouse lympholeukemia cells and human lymphocytes].
Dokl Akad Nauk SSSR. 1979;244(5):1266-70.
8
9
Differential effects of DNA synthesis inhibitors on DNA methylation in normal and transformed cells.DNA合成抑制剂对正常细胞和转化细胞中DNA甲基化的不同影响。
Anticancer Res. 1988 Jul-Aug;8(4):617-20.
10
Synchronization of L5178Y cells by treatment with hydroxyurea.通过羟基脲处理使L5178Y细胞同步化。
Arch Immunol Ther Exp (Warsz). 1975;23(5):693-9.
Zotero 插件