Pinel J P, Van Oot P H
Biol Psychiatry. 1977 Aug;12(4):479-86.
Repeated electroconvulsive shocks (ECSs) administered once every 3 days to rats at either of two current intensities led to a progressive intensification of the motor seizure pattern. Moreover, the incidence of convulsive symptoms elicited by subsequent alcohol exposure and withdrawal was greatly increased by prior exposure to the repeated ECSs. These results illustrate a treatment--drug interaction which could have hazardous consequences for patients undergoing electroconvulsive therapy. Thus, until the appropriate tests can be conducted on human patients, drug intake following electroconvulsive therapy should be carefully regulated.
以两种电流强度之一，每隔3天对大鼠进行一次反复电惊厥休克（ECS），会导致运动性癫痫发作模式逐渐加剧。此外，先前暴露于反复的ECS会大大增加随后酒精暴露和戒断引发的惊厥症状的发生率。这些结果说明了一种治疗 - 药物相互作用，这可能对接受电惊厥治疗的患者产生有害后果。因此，在对人类患者进行适当测试之前，应谨慎规范电惊厥治疗后的药物摄入。
