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[心得安影响下酪胺依赖性去甲肾上腺素在心脏各部位释放的实验研究结果]

[Experimental findings on tyramine-dependent release of noradrenaline in various parts of the heart under the influence of practolol].

作者信息

Brisse B, Bender F

出版信息

Z Kardiol. 1975 Oct;64(10):941-4.

PMID:56095
Abstract

Determinations of Noradrenaline-concentrations (NA) in the myocardium of the atria and ventricles of rats were performed and the influences of Practolol and Tyramine were controlled. Following Tyramine, NA was decreased significantly in all specimens. After preinjection of Practolol, NA depletion was considerably less in the right and left atria compared to control values. By these results, the clinical observation of a preferential antiarrhythmic action of Practolol on atrial extrasystoles and tachycardias may be supported.

摘要

测定了大鼠心房和心室心肌中的去甲肾上腺素浓度（NA），并研究了心得宁和酪胺的影响。注射酪胺后，所有标本中的NA均显著降低。预先注射心得宁后，与对照值相比，左右心房中的NA耗竭明显减少。这些结果可能支持了心得宁对房性早搏和心动过速具有优先抗心律失常作用的临床观察。

相似文献

1
[Experimental findings on tyramine-dependent release of noradrenaline in various parts of the heart under the influence of practolol].[心得安影响下酪胺依赖性去甲肾上腺素在心脏各部位释放的实验研究结果]
Z Kardiol. 1975 Oct;64(10):941-4.
2
Proceedings: Influence of propranolol and practolol on the turnover of noradrenaline in the rat heart.论文集：普萘洛尔和普拉洛尔对大鼠心脏去甲肾上腺素周转的影响
Naunyn Schmiedebergs Arch Pharmacol. 1974;282(Suppl):suppl 282:R57.
3
Retention of exogenous norepinephrine and recovery of the responses to tyramine and 1,1-dimethyl-4-phenylpiperazinium iodide after reserpine.利血平处理后外源性去甲肾上腺素的保留以及对酪胺和碘化1,1 - 二甲基 - 4 - 苯基哌嗪反应的恢复
J Pharmacol Exp Ther. 1966 Sep;153(3):434-9.
4
Norepinephrine depletion and sensitivity changes in rat heart induced by pretreatment with reserpine.利血平预处理诱导大鼠心脏去甲肾上腺素耗竭及敏感性变化。
J Pharmacol Exp Ther. 1987 Mar;240(3):764-71.
5
Restoration of cardiac responsiveness to tyramine after reserpine.利血平作用后心脏对酪胺反应性的恢复
J Pharmacol Exp Ther. 1968 Mar;160(1):53-60.
6
Effect of beta adrenergic blocking on the arrhythmias following coronary ligation in rat.β肾上腺素能阻断对大鼠冠状动脉结扎后心律失常的影响。
Acta Physiol Acad Sci Hung. 1973;44(3-4):247-57.
7
Differential blockade of guinea-pig atrial rate and force responses to (--)-noradrenaline by practolol - an uptake phenomenon.
Eur J Pharmacol. 1975 Nov;34(1):207-17. doi: 10.1016/0014-2999(75)90241-1.
8
Paradoxical action of desipramine on the modulatory effect of bradykinin on noradrenaline release in a model of metabolic anoxia in rat isolated atria.在大鼠离体心房代谢性缺氧模型中，地昔帕明对缓激肽调节去甲肾上腺素释放的作用具有矛盾性。
Can J Physiol Pharmacol. 1997 Jun;75(6):646-51.
9
[Anti-arrhythmia agents].[抗心律失常药物]
Med Klin. 1974 May 3;69(18):778-86.
10
Proceedings: Influence of oxymetazoline and phentolamine on noradrenaline (NA) release caused by electrical stimulation, potassium, tyramine and dimethylphenylpiperazine (DMPP).论文集：羟甲唑啉和酚妥拉明对电刺激、钾、酪胺和二甲基苯基哌嗪（DMPP）引起的去甲肾上腺素（NA）释放的影响。
Naunyn Schmiedebergs Arch Pharmacol. 1974;282(Suppl):suppl 282:R95.