Gramsch C, Bläsig J, Herz A
Eur J Pharmacol. 1977 Aug 1;44(3):231-40. doi: 10.1016/0014-2999(77)90070-x.
Precipitation of withdrawal in morphine tolerant/dependent rats by either naloxone or the partial agonist ZK 48491 caused a significant increase in the contration of striatal DA, which persisted for at least 1 h. During the same time the probenecid-induced accumulation of HVA and DOPAC was reduced in the striatum in relation to probenecid-treated tolerant/dependent controls. 20 min after precipitation of withdrawal by naloxone, the striatal concentration of 3-methoxytyramine was decreased by about 40%, while the activity of the DA metabolizing enzymes, MAO and COMT, remained unchanged. Naloxone-precipitated withdrawal was, further, found to delay the depletion of striatal DA caused by inhibition of synthesis 90 min after alpha-methyl-p-tyrosine treatment. All these results provide evidence for a decreased release of DA from the striatum during precipitated morphine withdrawal.
纳洛酮或部分激动剂ZK 48491诱发吗啡耐受/依赖大鼠出现戒断反应时，纹状体多巴胺（DA）浓度显著升高，且至少持续1小时。同时，与丙磺舒处理的耐受/依赖对照组相比，丙磺舒诱导的纹状体中高香草酸（HVA）和3,4-二羟基苯乙酸（DOPAC）蓄积减少。纳洛酮诱发戒断反应20分钟后，3-甲氧基酪胺的纹状体浓度降低约40%，而DA代谢酶单胺氧化酶（MAO）和儿茶酚-O-甲基转移酶（COMT）的活性保持不变。此外，还发现纳洛酮诱发的戒断反应会延迟α-甲基对酪氨酸处理90分钟后因合成抑制导致的纹状体DA耗竭。所有这些结果都证明，在诱发吗啡戒断反应期间，纹状体DA的释放减少。
