Effect of cholinesterase inhibitors on differentiation of cultured sympathicoblasts.

The 2 cholinesterase inhibitors, eserine and BW 284C 51, inhibited the nerve fibre growth and differentiation of immature sympatheticoblasts at low concentrations. The effect was nerve cell-specific and appeared in the course of the in vitro development, indicating that cholinesterases might play an important role in the early differentiation of sympathicoblasts.