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抗肿瘤剂XXIII:土木香内酯,一种来自玉山香青的抗肿瘤成分。

Antitumor agents XXIII: Helenalin, and antitumor principle from Anaphalis morrisonicola HAY.

作者信息

Lee K H, Haruna M, Huang H C, Wu B S, Hall I H

出版信息

J Pharm Sci. 1977 Aug;66(8):1194-5. doi: 10.1002/jps.2600660836.

DOI:10.1002/jps.2600660836
PMID:561183
Abstract

A chloroform extract of the whole plant of Anaphalis morrisonicola HAY, showed significant antitumor activity against Ehrlich ascites carcinoma, Walker 256 carcinosarcoma, and P-388 lymphocytic leukemia. Systematic fractionation of the extract led to isolation and characterization of helenalin, a pseudoguaianolide, as the major active principle.

摘要

玉山香青全株的氯仿提取物对艾氏腹水癌、沃克256癌肉瘤和P - 388淋巴细胞白血病显示出显著的抗肿瘤活性。对该提取物进行系统分离,得到了一种假愈创木烷型倍半萜内酯——堆心菊灵,并将其鉴定为主要活性成分。

相似文献

1
Antitumor agents XXIII: Helenalin, and antitumor principle from Anaphalis morrisonicola HAY.抗肿瘤剂XXIII:土木香内酯,一种来自玉山香青的抗肿瘤成分。
J Pharm Sci. 1977 Aug;66(8):1194-5. doi: 10.1002/jps.2600660836.
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Antitumor agents XXXVIII: Isolation and structural elucidation of novel germacranolides and triterpenes from Elephantopus mollis.抗肿瘤剂XXXVIII:从软地胆草中分离并鉴定新型吉马烷型倍半萜内酯和三萜类化合物的结构
J Pharm Sci. 1980 Sep;69(9):1050-6. doi: 10.1002/jps.2600690917.
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Antitumor agents 32. Synthesis and antitumor activity of cyclopentenone derivatives related to helenalin.
J Med Chem. 1978 Aug;21(8):819-22. doi: 10.1021/jm00206a021.
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Tumor inhibitors. 114. Aloe emodin: antileukemic principle isolated from Rhamnus frangula L.肿瘤抑制剂。114. 芦荟大黄素:从鼠李中分离出的抗白血病成分。
Lloydia. 1976 Jul-Aug;39(4):223-4.
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Antitumor activity of Anaphalis morrisonicola.
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Antitumor agents 37. The isolation and structural elucidation of isohelenol, a new antileukemic sesquiterpene lactone, and isohelenalin from Helenium microcephalum.抗肿瘤剂37. 从小头堆心菊中分离并鉴定新的抗白血病倍半萜内酯异堆心菊醇和异堆心菊内酯的结构。
J Nat Prod. 1979 May-Jun;42(3):282-6. doi: 10.1021/np50003a007.
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Isolation of methyl gallate as the antitumor principle of Acer saccharinum.
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[The isolation of antitumor active principle of Crotalaria sessiliflora and synthesis of its derivatives (author's transl)].
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