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几种真核细胞28S核糖体RNA中靠近晚期修饰鸟苷酸残基的核苷酸序列。

Nucleotide sequence neighbouring a late modified guanylic residue within the 28S ribosomal RNA of several eukaryotic cells.

作者信息

Eladari M E, Hampe A, Galibert F

出版信息

Nucleic Acids Res. 1977 Jun;4(6):1759-67. doi: 10.1093/nar/4.6.1759.

Abstract

The nucleotide sequence of a particular T1 oligonucleotide found in 41S and 28S RNAs of several cellular cell lines (human, mouse, rat and chicken fibroblast) but absent in 45S ribosomal RNA has been deduced. Its primary structure : A-U-U*-G*-psi-U-C-A-C-C-C-A-C-U-A-A-U-A-Gp shows the presence of a modified G residue which explains the existence of this oligonucleotide in the T1 fingerprint of 41S RNA and 28S. Its absence on the 45S RNA T1 fingerprint is accounted for by a late modification.

摘要

已推导得出一种特定T1寡核苷酸的核苷酸序列,该序列存在于几种细胞系(人、小鼠、大鼠和鸡成纤维细胞)的41S和28S RNA中,但在45S核糖体RNA中不存在。其一级结构:A-U-U*-G*-ψ-U-C-A-C-C-C-A-C-U-A-A-U-A-Gp显示存在一个修饰的G残基,这解释了该寡核苷酸在41S RNA和28S的T1指纹图谱中的存在。其在45S RNA T1指纹图谱中的缺失是由后期修饰导致的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/268f/342519/3828c2b7685e/nar00479-0071-a.jpg

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