Wada Y
Jpn Circ J. 1976 Mar;40(3):249-50, 275-86.
It has long been demonstrated that in cardiac muscle alterations in the extracellular pH exhibit a remarkable inotropic effect, whereas the precise mechanism is not fully clarified yet in spite of many associated thories. In recent years, however, abundant informations about the processes of excitation-contraction coupling (E-C coupling) of cardiac muscle have been obtained. Accordingly, the mechanisms of inotropic actions of pH on cardiac muscles must also be re-examined on the basis of these lately developed theories of E-C coupling. In the present experiment, therefore, we attempted to elucidate the fundamental mechanism of actions of pH upon several processes of E-C coupling using the bullfrog atrium whose processes of E-C coupling have been fairly well known...
长期以来业已证明，在心肌中细胞外pH值的改变呈现出显著的变力效应，然而尽管有许多相关理论，但确切机制尚未完全阐明。不过，近年来已获得了关于心肌兴奋-收缩偶联（E-C偶联）过程的大量信息。因此，也必须基于这些最新发展的E-C偶联理论，重新审视pH值对心肌的变力作用机制。所以，在本实验中，我们试图利用牛蛙心房来阐明pH值对E-C偶联若干过程的作用基本机制，牛蛙心房的E-C偶联过程已为人熟知……
