Wewalka F
Infusionsther Klin Ernahr. 1977 Aug;4(4):246-9.
Looking back over the past centuries, a survey shows that for the past 2000 years definite dietetic rules have existed for the treatment of liver diseases, which to a great extent have disregarded the distribution of protein and carbohydrates. Deviations from the principles of nutrition followed as a result of intensive physiological-chemical research during the 19th century. This new knowledge, however, lead to misinterpretation and exaggerations in the recommended dietary proportions of fat, protein and carbohydrates. Protein deficiency, which is particularly disadvantageous in cases of hepatitis during pregnancy, and lack of vitamins, along with other types of malnutrition, became apparent. Various attempts providing diets rich in protein and fat, for the treatment of hepatitis, proved rather the tolerance of these nutrients than discovering a new, more efficient therapy. In spite of some resignation, recommendations made on the basis of experience should rather be dispensed with, as regards diet, and the search for further knowledge of the supply of nutrients in liver diseases should be continued. In addition, the study of endotoxins and toxic amines in the metabolism of the brain offers a source of future research.
回顾过去几个世纪,一项调查显示,在过去2000年里,存在着明确的饮食规则用于治疗肝脏疾病,这些规则在很大程度上忽视了蛋白质和碳水化合物的分配。19世纪由于深入的生理化学研究,营养原则出现了偏差。然而,这些新知识导致了在推荐的脂肪、蛋白质和碳水化合物饮食比例上的误解和夸大。蛋白质缺乏在妊娠期肝炎病例中尤其不利,维生素缺乏以及其他类型的营养不良也变得明显。为治疗肝炎而尝试提供富含蛋白质和脂肪的饮食,结果更多地证明了这些营养素的耐受性,而非发现了一种新的、更有效的疗法。尽管有些无奈,但基于经验提出的饮食建议还是应该摒弃,应继续探索关于肝脏疾病营养供应的更多知识。此外,对大脑代谢中内毒素和有毒胺的研究为未来的研究提供了一个方向。