Patterson E C, Staszak D J
J Nutr. 1977 Nov;107(11):2020-5. doi: 10.1093/jn/107.11.2020.
Geophagia, in the form of clay-eating, is often observed during pregnancy in the human population. The intent of this study was to determine the effects of kaolin (clay) ingestion on the maternal blood and embryonic development of the pregnant rat. Thirty-six Sprague-dawley female rats were divided into three groups: control diet, 20% kaolin diet, and iron-supplemented 20% kaolin diet. The diets were fed 37 to 68 days, 69 to 95 days, and 96 to 117 days prior to fertilization, and the same diets were fed for the duration of the gestation period. The rats fed the kaolin diet exhibited significant reductions in hemoglobin, hematocrit, and red blood cell levels, thus indicating maternal anemia. There was also a significant reduction in the birth weight of the pups born to kaolin fed rats. The kaolin fed rats receiving an iron supplement maintained hematocrit, hemoglobin, red blood cell levels, and pup weight within the normal range.
在人类孕期，常可见到以食土形式表现的异食癖。本研究的目的是确定摄入高岭土（黏土）对妊娠大鼠母体血液及胚胎发育的影响。将36只斯普拉格 - 道利雌性大鼠分为三组：对照饮食组、20%高岭土饮食组和补充铁的20%高岭土饮食组。在受精前37至68天、69至95天和96至117天喂养这些饮食，妊娠期全程也喂养相同的饮食。喂食高岭土饮食的大鼠血红蛋白、血细胞比容和红细胞水平显著降低，表明母体贫血。喂食高岭土的大鼠所产幼崽的出生体重也显著降低。接受铁补充剂的喂食高岭土的大鼠血细胞比容、血红蛋白、红细胞水平和幼崽体重维持在正常范围内。
