Kosakai N, Oguri T
Jpn J Antibiot. 1976 Mar;29(3):229-37.
We studied on the antibacterial activity of gentamicin against various pathogens isolated from clinical materials mainly isolated during 1974 and 1975, comparing with other antibiotics. Beta hemolytic streptococci, pneumococci and enterococci are less susceptible to gentamicin than staphylococci. Staph, aureus and Staph. epidermidis resistant to various antibiotics are very susceptible to gentamicin, and no resistant strain to this drug was found. Haemophilus influenzae, H. parainfluenzae and H. parahaemolyticus are very susceptible to gentamicin, and there is no resistant strain to this drug. Escherichia coli, Klebsiella, Citrobacter, Serratia and five species of Proteus are more susceptible to gentamicin and tobramycin than dibekacin and amikacin. A few resistant or less susceptible strains to gentamicin are found in E. coli, Citrobacerr, Serratia, Pr. morganii and Pr. rettgeri. Pr. inconstans is less susceptible to gentamicin than other species of Proteus. Antibacterial activity of gentamicin against Pseudomonas aeruginosa is very strong, but dibekacin and tobramycin are stronger. Gentamicin-resistant strains of Pseudomonas aeruginosa are now rather few.
我们研究了庆大霉素对主要于1974年和1975年从临床材料中分离出的各种病原体的抗菌活性,并与其他抗生素进行了比较。β溶血性链球菌、肺炎球菌和肠球菌对庆大霉素的敏感性低于葡萄球菌。对各种抗生素耐药的金黄色葡萄球菌和表皮葡萄球菌对庆大霉素非常敏感,未发现对该药物耐药的菌株。流感嗜血杆菌、副流感嗜血杆菌和副溶血性嗜血杆菌对庆大霉素非常敏感,也未发现对该药物耐药的菌株。大肠杆菌、克雷伯菌属、柠檬酸杆菌属、沙雷菌属和五种变形杆菌对庆大霉素和妥布霉素的敏感性高于地贝卡星和阿米卡星。在大肠杆菌、柠檬酸杆菌属、沙雷菌属、摩根氏变形杆菌和雷氏变形杆菌中发现了一些对庆大霉素耐药或敏感性较低的菌株。可变变形杆菌对庆大霉素的敏感性低于其他变形杆菌属。庆大霉素对铜绿假单胞菌的抗菌活性很强,但地贝卡星和妥布霉素更强。现在对庆大霉素耐药的铜绿假单胞菌菌株相当少。