Grubb R L, Raichle M E, Gado M H, Eichling J O, Hughes C P
Neurology. 1977 Oct;27(10):905-10. doi: 10.1212/wnl.27.10.905.
Patients with dementia had significant decreases in cerebral blood flow and cerebral oxygen utilization and a mild, but not significant, increase in cerebral blood volume. These studies were not useful in distinguishing patients with cerebral atrophy from patients with normal pressure hydrocephalus, as similar changes in cerebral circulation and metabolism were seen in both groups. Changes in cerebral blood flow after acute decrease in the intracranial pressure also were not helpful differentiating patients with normal pressure hydrocephalus from patients with cerebral atrophy.
痴呆患者的脑血流量和脑氧利用率显著降低，脑血容量有轻微但不显著的增加。这些研究对于区分脑萎缩患者和正常压力脑积水患者并无帮助，因为两组患者的脑循环和代谢均出现了类似变化。颅内压急性降低后脑血流量的变化，对于区分正常压力脑积水患者和脑萎缩患者也没有帮助。
