Jones R W, Asher M I, Rutherford C J, Munro H M
Br J Obstet Gynaecol. 1977 Sep;84(9):679-83. doi: 10.1111/j.1471-0528.1977.tb12680.x.
The effects of autoimmune (or idiopathic) thrombocytopenic purpura (ATP) on 51 pregnancies in 29 women is presented. There is no convincing evidence that the clinical course of ATP is influenced by pregnancy. There was no increased incidence of obstetric complications. No problems were encountered following spontaneous vaginal delivery or low forceps delivery. There were no perinatal deaths. Twenty newborn infants were studied in detail and significant thrombocytopenia was present in half of them. The severity of thrombocytopenia in the newborn correlated closely with the severity of maternal disease; those women in clinical remission following splenectomy but with presumed high levels of antiplatelet antibodies were those most likely to be delivered of affected newborn infants. The cord blood platelet count was the most reliable guide to the potential severity of the neonatal thrombocytopenia. Platelet counts were lowest between the second and fourth days of neonatal life. The management of the severely affected infant is discussed.
本文介绍了自身免疫性（或特发性）血小板减少性紫癜（ATP）对29名女性51次妊娠的影响。没有令人信服的证据表明妊娠会影响ATP的临床病程。产科并发症的发生率没有增加。自然阴道分娩或低位产钳分娩后未出现问题。没有围产期死亡。对20名新生儿进行了详细研究，其中一半存在明显的血小板减少。新生儿血小板减少的严重程度与母亲疾病的严重程度密切相关；脾切除术后临床缓解但推测抗血小板抗体水平较高的女性，其新生儿最有可能受到影响。脐血血小板计数是新生儿血小板减少潜在严重程度的最可靠指标。血小板计数在新生儿出生后第二至第四天最低。本文还讨论了对严重受影响婴儿的处理。
