Pohorecky L A, Newman B
Drug Alcohol Depend. 1977 Sep-Nov;2(5-6):329-34. doi: 10.1016/0376-8716(77)90035-7.
We have examined the effects of acute and chronic ethanol treatment and of ethanol withdrawal on dopamine synthesis in rat striatal synaptosomes in vitro. Our studies showed that acute exposure to ethanol produces a dose-related decrease in dopamine synthesis in synaptosomes. This effect of acute ethanol treatment is time-dependent, since there is an initial stimulation of dopamine synthesis, which then is followed by a depression of synthesis. Chronic exposure to ethanol in the form of a liquid diet for 2 weeks does not alter dopamine synthesis in striatal synaptosomes. After withdrawal from ethanol, dopamine synthesis in striatal synaptosomes is decreased.
我们已经研究了急性和慢性乙醇处理以及乙醇戒断对体外培养的大鼠纹状体突触体中多巴胺合成的影响。我们的研究表明，急性暴露于乙醇会导致突触体中多巴胺合成呈剂量依赖性减少。急性乙醇处理的这种效应是时间依赖性的，因为最初会刺激多巴胺合成，随后合成会受到抑制。以液体饲料形式慢性暴露于乙醇2周不会改变纹状体突触体中的多巴胺合成。乙醇戒断后，纹状体突触体中的多巴胺合成减少。
