Hogh P
Acta Vet Scand. 1967;8(4):301-23. doi: 10.1186/BF03547819.
Necrotizing enteritis in piglets caused by Clostridium perfringens type C has been diagnosed in 32 Danish herds of swine (status as at March 1, 1967), the geographical location of which (Fig. 1) shows the enzootic character of the disease. The disease occurs both in small and large herds, and is characterized by a high mortality during the first week of life (Fig. 5). The mortality does not seem to be influenced either by the size of litter (Fig. 4) or by the state of health of the sows (Table 1). After an incubation period varying from a few hours to a few days, the piglets develop symptoms of enteritis or gastro-enteritis with general malaise and anorexia. The disease, the course of which varies from about 12 hrs. to a few days, ends in coma and death. The body temperature usually remains normal, but may be subnormal or subfebrile. The disease is accompained by hypoglycaemia and increased blood urea (Fig. 7). In peracute cases there is leukopenia, with some shift to the left of the heterophilic granulocytes. There is also leukopenia in subacute cases, but as regards the heterophils this is partly offset by a marked increase in the number of juvenile heterophils. Eosinopenia is another characteristic haematological finding (Table 3). In the differential diagnosis; special attention should, under Danish conditions, be paid to E. coli infections in new-born piglets.
由C型产气荚膜梭菌引起的仔猪坏死性肠炎已在32个丹麦猪群中被诊断出来（截至1967年3月1日的情况），其地理位置（图1）显示了该病的地方流行性特征。这种疾病在大小猪群中均有发生，其特点是仔猪出生后第一周死亡率很高（图5）。死亡率似乎不受窝仔数大小（图4）或母猪健康状况（表1）的影响。经过从几小时到几天不等的潜伏期后，仔猪会出现肠炎或肠胃炎症状，并伴有全身不适和食欲不振。该病病程从约12小时到几天不等，最终以昏迷和死亡告终。体温通常保持正常，但可能低于正常或微热。该病伴有低血糖和血尿素升高（图7）。在最急性病例中，会出现白细胞减少，伴有一些嗜异性粒细胞左移。亚急性病例中也有白细胞减少，但就嗜异性粒细胞而言，这部分被幼年嗜异性粒细胞数量的显著增加所抵消。嗜酸性粒细胞减少是另一个特征性血液学表现（表3）。在鉴别诊断中；在丹麦的情况下，应特别注意新生仔猪的大肠杆菌感染。
