Cetta G, Pallavicini G, Tenni R, Bisi C
Ital J Biochem. 1977 Jul-Aug;26(4):317-27.
A protective and curative effect of some flavonoids on collagen maturation in lathyrism has been previously demonstrated. This action appeared to involve cross linking of collagen. This paper deals with the effect in vitro of flavonoids and flavonoid-copper complexes on the oxidative deamination of lysine epsilon-amino groups in [4,5-3H]-lysine-labelled elastin. Flavonoids alone do not affect the reaction but it is evident that some flavonoid copper complexes are strongly effective: the aldehyde groups that are quickly formed then enable cross linking to occur. The lysine epsilon-amino groups of elastin are specifically concerned: in fact no effect was observed on free [4,5-3H]-lysine or on [4,5-3H]-lysine-labelled proteins obtained from mouse liver. The lysyl oxidase seems to interfere with the flavonoid-copper complees to regulate the oxidative deamination of lysine epsilon-amino groups.
先前已证明某些黄酮类化合物对山黧豆中毒中胶原蛋白成熟具有保护和治疗作用。这种作用似乎涉及胶原蛋白的交联。本文探讨了黄酮类化合物和黄酮类铜络合物对[4,5-³H]-赖氨酸标记的弹性蛋白中赖氨酸ε-氨基氧化脱氨的体外作用。单独的黄酮类化合物不影响该反应，但显然某些黄酮类铜络合物具有很强的效果：快速形成的醛基随后能够发生交联。弹性蛋白的赖氨酸ε-氨基受到特别关注：事实上，对游离的[4,5-³H]-赖氨酸或从小鼠肝脏获得的[4,5-³H]-赖氨酸标记的蛋白质未观察到影响。赖氨酰氧化酶似乎会干扰黄酮类铜络合物，以调节赖氨酸ε-氨基的氧化脱氨。
