大鼠蓝斑双侧损伤后抗精神病药物、阿扑吗啡和苯丙胺的行为效应。
Behavioral effects of neuroleptics, apomorphine and amphetamine after bilateral lesion of the locus coeruleus in rats.
作者信息
Kostowski W, Jerlicz M, Bidzinski A, Hauptmann M
出版信息
Pharmacol Biochem Behav. 1977 Oct;7(4):289-93. doi: 10.1016/0091-3057(77)90222-2.
PMID:563082
Abstract
Bilateral lesions of the locus coeruleus (LC) markedly increased susceptibility to the cateleptogenic effects of neuroleptics. The apomorphine-induced stereotypy was enhanced in rats with lesioned LC whilst amphetamine stereotypy was only slightly increased. No changes in locomotor activity have been observed in LC-lesioned rats treated with apomorphine and amphetamine. This data indicates that lesions of the LC produce decreased activity of dopaminergic brain neurons as well as supersensitivity of dopaminergic receptors.
摘要
蓝斑（LC）的双侧损伤显著增加了对神经阻滞剂致僵效应的易感性。在LC损伤的大鼠中，阿扑吗啡诱导的刻板行为增强，而苯丙胺刻板行为仅略有增加。在用阿扑吗啡和苯丙胺治疗的LC损伤大鼠中，未观察到运动活动的变化。该数据表明，LC损伤导致多巴胺能脑神经元活性降低以及多巴胺能受体超敏反应。
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