Paegle R D, Bernhard W N, Turndorf H
Anesth Analg. 1977 Nov-Dec;56(6):847-51. doi: 10.1213/00000539-197711000-00020.
Prior intermittent exposure to 40 percent O2 protected rats against fatal O2 toxicity. Protection was not absolute, however, for the death of most rats in 100 percent O2 was not prevented but delayed considerably. Furthermore, those rats which did survive exposure to 100 percent O2 for long periods by virtue of prior-adaptation to increased O2 concentrations had pathologic changes in the lungs typical of chronic O2 toxicity. The very early demise of some rats indicated that 1 of 12 animals is hypersenstiive to high concentrations of inspired O2.
先前间歇性暴露于40%的氧气中可保护大鼠免受致命的氧中毒。然而，这种保护并非绝对的，因为大多数置于100%氧气环境中的大鼠虽未被阻止死亡，但死亡时间被显著延迟。此外，那些因预先适应了较高氧气浓度而在100%氧气环境中长时间存活下来的大鼠，肺部出现了典型的慢性氧中毒病理变化。一些大鼠过早死亡表明，每12只动物中有1只对高浓度吸入氧气高度敏感。
