普萘洛尔对甲状腺功能亢进症患者葡萄糖耐量的影响。
Effect of propranolol on glucose tolerance in hyperthyroidism.
作者信息
Harrower A D, Nairn I M, Strong J A
出版信息
Postgrad Med J. 1977 Nov;53(625):687-90. doi: 10.1136/pgmj.53.625.687.
Glucose tolerance tests were performed on six hyperthyroid patients in the morning and afternoon before, and at the end of treatment with propranolol for 2 weeks. All six subjects showed normal glucose tolerance with a normal diurnal rhythm before treatment and this remained normal in five during treatment with propranolol, while one patient developed abnormal glucose tolerance and the diurnal variation was abolished. No change in insulin levels was noted in any of the patients either before or during treatment. Propranolol may cause deterioration in glucose tolerance in some subjects with hyperthyroidism and this possibility should not be overlooked.
对6名甲状腺功能亢进患者在服用普萘洛尔治疗前、治疗2周结束时的上午和下午进行了葡萄糖耐量试验。所有6名受试者在治疗前葡萄糖耐量正常，昼夜节律正常，在使用普萘洛尔治疗期间，5名患者仍保持正常，而1名患者出现葡萄糖耐量异常，昼夜变化消失。在任何患者治疗前或治疗期间均未观察到胰岛素水平的变化。普萘洛尔可能会使一些甲状腺功能亢进患者的葡萄糖耐量恶化，这种可能性不应被忽视。
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