Ashley D J
Thorax. 1968 Jan;23(1):87-91.
The clinical, histological, and biological features of 157 lung cancers in coal miners and ex-miners are presented. In most respects—age, bronchoscopic appearances, histological type, and symptoms —the two groups are similar. A high incidence of dyspnoea in the miners was attributed to the concurrence of chronic bronchopulmonary disease. A striking feature was the lower frequency with which lung cancer in miners was found to be operable. It was suggested that the lower frequency of lung cancer in miners is related to an enhancement of the state of immunological preparedness in the lung related to the immune component in the pathogenesis of pneumoconiosis. The differences in lung cancer between miners and non-miners may be partially explained in this way.
本文介绍了157例煤矿工人和曾经的煤矿工人肺癌的临床、组织学和生物学特征。在大多数方面，如年龄、支气管镜表现、组织学类型和症状，这两组患者相似。矿工中呼吸困难的高发病率归因于慢性支气管肺部疾病的并发。一个显著特征是矿工中可手术肺癌的发现频率较低。有人提出，矿工中肺癌发生率较低与尘肺病发病机制中免疫成分相关的肺部免疫准备状态增强有关。矿工与非矿工肺癌的差异可能部分以此来解释。
