牛外周血淋巴细胞对B族链球菌细胞抗原和植物血凝素刺激的体外反应。
In vitro response of the bovine peripheral lymphocyte to stimulation with cellular antigens of group B streptococcus and phytohaemagglutinin.
作者信息
Kelly R H
出版信息
Immunology. 1968 Feb;14(2):175-80.
This investigation was conducted in two parts: first establishing separatory and cultural procedures for bovine lymphocytes, and then studying the response of these cells following stimulation with phytohaemagglutinin (PHA) and cellular constituents of . Peripheral lymphocytes from normal animals, those with chronic udder infections, and animals hyperimmunized with cellular constituents of were studied. The bovine lymphocyte responded to PHA with blastogenic changes similar to those of the human lymphocyte. No changes in cellular morphology or cytochemistry were detected following stimulation with cell antigens of Lymphocytes from hyperimmunized animals were shown to be capable of transformation in response to a different antigenic stimulation. Several explanations for this immunological inertia are presented.
本研究分两部分进行
首先建立牛淋巴细胞的分离和培养程序，然后研究这些细胞在用植物血凝素（PHA）和[具体物质]的细胞成分刺激后的反应。对来自正常动物、患有慢性乳房感染的动物以及用[具体物质]的细胞成分进行超免疫的动物的外周淋巴细胞进行了研究。牛淋巴细胞对PHA的反应表现出与人类淋巴细胞相似的致有丝分裂变化。在用[具体物质]的细胞抗原刺激后，未检测到细胞形态或细胞化学的变化。超免疫动物的淋巴细胞显示能够对不同的抗原刺激做出转化反应。针对这种免疫惰性提出了几种解释。
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