Klykova G T
Zh Mikrobiol Epidemiol Immunobiol. 1977 Dec(12):64-70.
A five-fold administration to Wistar rats of crystalline bovine trypsin in a dose of 0.01 mg per 100 g of body weight stimulated formation of rosette forming cells (RFC) and antibody forming cells (AFC) in the spleen in injection of the antigen 2 hours after the termination of trypsin treatment, but failed to influence the immune response in case of immunization 48 hours after the terminal injection of the enzyme. The blood serum of rats, obtained 2 hours after the last trypsin injection stimulated in passive homologous transfer the RFC and the AFC formation and also accelerated tha antibody production. As to serum obtained 48 hours after the termination of trypsinization, it had no effect on the development of the immunological response.
以每100克体重0.01毫克的剂量给Wistar大鼠五次注射结晶牛胰蛋白酶，在胰蛋白酶处理结束后2小时注射抗原时，刺激脾脏中玫瑰花结形成细胞（RFC）和抗体形成细胞（AFC）的形成，但在酶的末次注射后48小时进行免疫时，未能影响免疫反应。在最后一次注射胰蛋白酶后2小时获得的大鼠血清，在被动同源转移中刺激RFC和AFC的形成，并加速抗体产生。至于胰蛋白酶处理结束后48小时获得的血清，对免疫反应的发展没有影响。
