来自感觉神经节的类甾醇化合物。神经生长因子和胰岛素对其生物合成的影响。
Sterol-like compound from sensory ganglia. Effect of a nerve growth factor and insulin on its biosynthesis.
作者信息
Liuzzi A, Foppen F H
出版信息
Biochem J. 1968 Mar;107(2):191-6. doi: 10.1042/bj1070191.
Abstract
- Sensory ganglia from 8-day-old chick embryos were incubated with a specific nerve growth factor and with insulin. 2. From the total lipid extract of the ganglia a compound with steroid characteristics was isolated. 3. The synthesis of this compound, measured spectrophotometrically, diminished after addition of the nerve growth factor and insulin to the incubation medium. 4. The incorporation of sodium [2-(14)C]acetate and dl-[2-(14)C]mevalonic acid into total lipids of the sensory ganglia was stimulated by the nerve growth factor and insulin, but the radioactivity of the sterol-like compound was slightly lower. The incorporation of labelled mevalonic acid either into total lipids or into the sterol-like compound was about 25% lower. 5. About 20% of the acetate incorporated into total lipids and about 87% of the mevalonic acid were recovered in the sterol-like compound.
摘要
- 将8日龄鸡胚的感觉神经节与特定的神经生长因子和胰岛素一起孵育。2. 从神经节的总脂质提取物中分离出一种具有类固醇特征的化合物。3. 通过分光光度法测定，在向孵育培养基中添加神经生长因子和胰岛素后，这种化合物的合成减少。4. 神经生长因子和胰岛素刺激了[2-(14)C]乙酸钠和dl-[2-(14)C]甲羟戊酸掺入感觉神经节的总脂质中，但类甾醇化合物的放射性略低。标记的甲羟戊酸掺入总脂质或类甾醇化合物中的量约低25%。5. 掺入总脂质中的乙酸约20%以及甲羟戊酸约87%在类甾醇化合物中被回收。
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