S-甲基-L-半胱氨酸的代谢
The metabolism of S-methyl-L-cysteine.
作者信息
Sklan N M, Barnsley E A
出版信息
Biochem J. 1968 Mar;107(2):217-23. doi: 10.1042/bj1070217.
Abstract
- Methylsulphinylacetic acid, 2-hydroxy-3-methylsulphinylpropionic acid and methylmercapturic acid sulphoxide (N-acetyl-S-methyl-l-cysteine S-oxide) were isolated as their dicyclohexylammonium salts from the urine of rats after they had been dosed with S-methyl-l-cysteine. 2. A fourth sulphoxide was isolated but not identified. 3. The excretion of sulphate in the urine of rats dosed with S-methyl-l-cysteine was measured. 4. The metabolism of S-methyl-l-cysteine by the hamster and guinea pig was examined chromatographically. 5. The preparation of the following compounds is reported: (-)-dicyclohexylammonium methyl-mercapturate sulphoxide; the dicyclohexylammonium salts of the optically inactive forms of 2-hydroxy-3-methylthiopropionic acid, 2-hydroxy-3-methyl-sulphinylpropionic acid and methylsulphinylacetic acid.
摘要
- 给大鼠投喂S-甲基-L-半胱氨酸后，从其尿液中分离出甲基亚磺酰乙酸、2-羟基-3-甲基亚磺酰丙酸和甲基巯基尿酸亚砜（N-乙酰基-S-甲基-L-半胱氨酸S-氧化物），并制成它们的二环己基铵盐。2. 分离出了第四种亚砜，但未鉴定。3. 测定了投喂S-甲基-L-半胱氨酸的大鼠尿液中硫酸盐的排泄量。4. 用色谱法研究了仓鼠和豚鼠对S-甲基-L-半胱氨酸的代谢。5. 报道了以下化合物的制备：（-）-二环己基铵甲基巯基尿酸亚砜；2-羟基-3-甲基硫代丙酸、2-羟基-3-甲基亚磺酰丙酸和甲基亚磺酰乙酸无旋光活性形式的二环己基铵盐。
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