海兔起搏神经元分离胞体中的自发活动。
Spontaneous activity in isolated somata of Aplysia pacemaker naurons.
作者信息
Alving B O
出版信息
J Gen Physiol. 1968 Jan;51(1):29-45. doi: 10.1085/jgp.51.1.29.
Abstract
Somata of pacemaker and nonpacemaker neurons were isolated by ligatures tied around the axons between the somata and the synaptic regions, and the transmembrane potentials of the isolated somata were recorded. Isolated somata of pacemaker neurons had a spontaneous discharge while isolated somata of nonpacemaker neurons were quiescent. In addition, the time course of accommodation in isolated somata of pacemaker and nonpacemaker neurons was found to be different. In pacemaker neurons, injection of current produced a change in rate of discharge sustained for the duration of current injection, while in nonpacemakers, current injection produced only a transient change in discharge rate. Evidence is presented that the pacemaker locus and spike trigger zone in the intact pacemaker neuron are located on the soma.
摘要
通过在神经元胞体与突触区域之间的轴突上结扎，分离出起搏神经元和非起搏神经元的胞体，并记录分离出的胞体的跨膜电位。起搏神经元的分离胞体有自发放电，而非起搏神经元的分离胞体则静止不动。此外，发现起搏神经元和非起搏神经元分离胞体的适应时间进程不同。在起搏神经元中，注入电流会使放电速率在电流注入持续期间持续变化，而在非起搏神经元中，注入电流只会使放电速率产生短暂变化。有证据表明，完整起搏神经元中的起搏位点和动作电位触发区位于胞体上。
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