酿酒酵母中α-甘油磷酸对乙酰辅酶A羧化酶的调控机制。
Mechanism of alpha-glycerophosphate regulation of acetyl-coenzyme A carboxylase of Saccharomyces cerevisiae.
作者信息
Rasmussen R K, Klein H P
出版信息
J Bacteriol. 1968 Mar;95(3):1090-3. doi: 10.1128/jb.95.3.1090-1093.1968.
Abstract
The mechanism proposed for the activation of animal acetyl-coenzyme A (CoA) carboxylase by alpha-glycerophosphate, namely, the removal of inhibitory palmityl-CoA via glyceride synthesis, is not the only possible one in the yeast system because extracts exhibiting marked stimulation of acetyl-CoA carboxylase activity by alpha-glyerophosphate show a lack of acyl-CoA compounds.
摘要
α-甘油磷酸激活动物乙酰辅酶A（CoA）羧化酶的机制，即通过甘油酯合成去除抑制性的棕榈酰辅酶A，在酵母系统中并非唯一可能的机制，因为那些被α-甘油磷酸显著刺激乙酰辅酶A羧化酶活性的提取物显示缺乏酰基辅酶A化合物。
相似文献
1
Mechanism of alpha-glycerophosphate regulation of acetyl-coenzyme A carboxylase of Saccharomyces cerevisiae.酿酒酵母中α-甘油磷酸对乙酰辅酶A羧化酶的调控机制。
J Bacteriol. 1968 Mar;95(3):1090-3. doi: 10.1128/jb.95.3.1090-1093.1968.
2
Activation of fatty acid synthesis in cell-free extracts of Saccharomyces cerevisiae.酿酒酵母无细胞提取物中脂肪酸合成的激活
J Bacteriol. 1968 Jan;95(1):157-61. doi: 10.1128/jb.95.1.157-161.1968.
3
Hormonal regulation of adipose-tissue acetyl-Coenzyme A carboxylase by changes in the polymeric state of the enzyme. The role of long-chain fatty acyl-Coenzyme A thioesters and citrate.通过改变酶的聚合状态对脂肪组织乙酰辅酶A羧化酶进行激素调节。长链脂肪酰辅酶A硫酯和柠檬酸的作用。
Biochem J. 1974 Aug;142(2):365-77. doi: 10.1042/bj1420365.
4
Effects of alpha-glycerophosphate and of palmityl-coenzyme A on lipid synthesis in yeast extracts.α-甘油磷酸酯和棕榈酰辅酶A对酵母提取物中脂质合成的影响。
J Bacteriol. 1966 Mar;91(3):1218-23. doi: 10.1128/jb.91.3.1218-1223.1966.
5
6
Liver acetyl CoA carboxylase: insight into the mechanism of activation by tricarboxylic acids and acetyl CoA.肝脏乙酰辅酶A羧化酶：对三羧酸和乙酰辅酶A激活机制的深入了解
Proc Natl Acad Sci U S A. 1967 May;57(5):1455-62. doi: 10.1073/pnas.57.5.1455.
7
Coenzyme A activation of acetyl-CoA carboxylase.辅酶A对乙酰辅酶A羧化酶的激活作用。
J Biol Chem. 1981 Mar 10;256(5):2289-96.
8
The participation of acetyl-CoA in pyruvate carboxylase.乙酰辅酶A在丙酮酸羧化酶中的参与情况。
Biochem Biophys Res Commun. 1966 Feb 3;22(3):285-90. doi: 10.1016/0006-291x(66)90479-7.
9
Liver levels of alpha-glycerophosphate, glycerophosphate dehydrogenase and acetyl-CoA carboxylase during phenobarbital induction.
FEBS Lett. 1975 Apr 1;52(2):240-1. doi: 10.1016/0014-5793(75)80814-3.
10
Regulation of acetyl-CoA carboxylase.乙酰辅酶A羧化酶的调节
Curr Top Cell Regul. 1983;22:143-76. doi: 10.1016/b978-0-12-152822-5.50009-9.
引用本文的文献
1
Repression of acetyl-coenzyme A carboxylase by unsaturated fatty acids: relationship to coenzyme repression.不饱和脂肪酸对乙酰辅酶A羧化酶的抑制作用：与辅酶抑制的关系。
J Bacteriol. 1970 Oct;104(1):171-6. doi: 10.1128/jb.104.1.171-176.1970.
本文引用的文献
1
Liver acetyl coa carboxylase: the dissociation-reassociation process and its relation to catalytic activity.肝脏乙酰辅酶A羧化酶：解离-重新结合过程及其与催化活性的关系。
Proc Natl Acad Sci U S A. 1966 Dec;56(6):1751-8. doi: 10.1073/pnas.56.6.1751.
2
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
3
The mechanism of tricarboxylic acid cycle regulation of fatty acid synthesis.三羧酸循环对脂肪酸合成的调控机制。
J Biol Chem. 1962 Jun;237:1787-92.
4
FACTORS AFFECTING FATTY ACID SYNTHESIS IN CELL-FREE PREPARATIONS FROM SACCHAROMYCES CEREVISIAE.影响酿酒酵母无细胞制剂中脂肪酸合成的因素
Biochem Biophys Res Commun. 1965 Jun 18;20:78-84. doi: 10.1016/0006-291x(65)90953-8.
5
6
THE EFFECT OF ALPH-GLYCEROPHOSPHATE ON THE MICROSOMAL STIMULATION OF FATTY ACID SYNTHESIS.α-甘油磷酸对脂肪酸合成微粒体刺激作用的影响
Biochim Biophys Acta. 1964 Apr 20;84:226-8. doi: 10.1016/0926-6542(64)90089-7.
7
THE INHIBITION OF ACETYL COA CARBOXYLASE BY LONG CHAIN ACYL COA DERIVATIVES.长链脂酰辅酶A衍生物对乙酰辅酶A羧化酶的抑制作用。
Biochem Z. 1963 Aug 14;337:505-9.
8
Activation of acetyl-CoA carboxylase and associated alteration of sedimentation characteristics of the enzyme.
Biochem Biophys Res Commun. 1962 Jun 19;8:4-8. doi: 10.1016/0006-291x(62)90224-3.
9
Studies on the mechanism of fatty acid synthesis. VII. Biosynthesis of fatty acids from malonyl CoA.脂肪酸合成机制的研究。VII. 由丙二酰辅酶A合成脂肪酸
Biochim Biophys Acta. 1960 May 6;40:110-8. doi: 10.1016/0006-3002(60)91320-2.
10
A rapid method of total lipid extraction and purification.一种快速的总脂质提取与纯化方法。
Can J Biochem Physiol. 1959 Aug;37(8):911-7. doi: 10.1139/o59-099.
Zotero 插件