Coster H G, George E P
Biophys J. 1968 Apr;8(4):457-69. doi: 10.1016/s0006-3495(68)86500-2.
Flux and flux-ratio equations are derived on the basis of the phenomenological equations of irreversible thermodynamics. Deviations of flux-ratios from that given by the often quoted Ussing (1949) relation are predicted, even in the absence of active transport, by considering the dependence of coupled fluxes on the membrane potential. The treatment is extended to include the interpretation of fluxes measured with tracers. Estimation of the numerical values of the resistance coefficients show that the voltage dependence of the entrainment terms can adequately account for the departures from the Ussing relation and the discrepancies between isotopically and electrically measured membrane conductances.
通量和通量比方程是基于不可逆热力学的唯象方程推导出来的。即使在没有主动转运的情况下，通过考虑耦合通量对膜电位的依赖性，预测通量比会偏离常被引用的乌辛（1949年）关系式所给出的值。该处理方法得到扩展，以包括对用示踪剂测量的通量的解释。电阻系数数值的估计表明，夹带项的电压依赖性能够充分解释与乌辛关系式的偏差以及同位素测量和电测量的膜电导之间的差异。
