促黑素细胞激素：α-氨基酸热聚合物中的活性

Melanocyte-stimulating hormone: activity in thermal polymers of alpha-amino acids.

作者信息

Fox S W, Wang C

出版信息

Science. 1968 May 3;160(3827):547-8. doi: 10.1126/science.160.3827.547.

DOI:10.1126/science.160.3827.547

Abstract

Thermal polymers of arginine, glutamic acid, glycine, histidine, phenylalanine, and tryptophan have melanocyte-stimulating activity. The fact that similar polymers lack such activity indicates that the effect is related to the specific amino acid residues. The active polymers are discussed as a model of an evolutionary precursor of contemporary melanocyte-stimulating hormone.

摘要

精氨酸、谷氨酸、甘氨酸、组氨酸、苯丙氨酸和色氨酸的热聚合物具有促黑素细胞活性。类似聚合物缺乏这种活性这一事实表明，该效应与特定氨基酸残基有关。活性聚合物被作为当代促黑素细胞激素进化前体的模型进行讨论。