Reitz B A, Stinson E B, Griepp R B, Shumway N E
Am J Cardiol. 1978 Mar;41(3):512-5. doi: 10.1016/0002-9149(78)90008-5.
Twenty-five patients who had repeated thromboemboli from a prosthetic mitral valve were treated with reoperation using a tissue valve prosthesis. Reoperation was performed an average of 4.0 years after the original valve replacement in 14 men and 11 women, with an average age of 50 (range 35 to 65) years. A stented allograft was used in the first 7 patients and a porcine xenograft in the last 18 patients. There were one hospital death and two late deaths. With the first prosthetic valve there were 66 documented embolic episodes in 101.5 patient years (0.65 embolus/year). Only four embolic episodes in 67.4 patient years (0.059 embolus/year) occurred after tissue valve replacement (P less than 0.001). These results indicate that in patients with recurrent or severe embolization after prosthetic heart valve replacement, rereplacement with a tissue prosthesis can be safely performed and significantly reduces the likelihood that additional embolic episodes will occur.
25例人工二尖瓣反复发生血栓栓塞的患者接受了使用组织瓣膜假体的再次手术治疗。再次手术在首次瓣膜置换术后平均4.0年进行，患者中有14名男性和11名女性，平均年龄50岁（范围35至65岁）。前7例患者使用带支架的同种异体移植物，后18例患者使用猪异种移植物。有1例医院死亡和2例晚期死亡。使用第一个人工瓣膜时，在101.5患者年中有66次记录的栓塞事件（0.65次栓塞/年）。组织瓣膜置换后在67.4患者年中仅发生4次栓塞事件（0.059次栓塞/年）（P小于0.001）。这些结果表明，对于人工心脏瓣膜置换术后复发或严重栓塞的患者，使用组织假体进行再次置换可以安全进行，并显著降低再次发生栓塞事件的可能性。
