Reitan J A, Stengert K B, Wymore M L, Martucci R W
Anesth Analg. 1978 Jan-Feb;57(1):31-6. doi: 10.1213/00000539-197801000-00007.
Six mongrel dogs were used to investigate the mechanism of action of fentanyl-induced bradycardia. With controlled acid-base balance and temperature, and under 1.0 to 1.2 percent endtidal halothane anesthesia, 5 and microgram/kg of IV fentanyl citrate were given sequentially 1 hour apart and heart rate (HR) followed for 60 minutes. A dose-related depression of HR followed both injections. One week later the same dogs were studied similarly, except that bilateral cervical vagotomies were performed before fentanyl was given. The decrease in HR was at most 10 percent of the decrease in HR observed in the innervated dogs. Serum fentanyl levels were comparable. The data indicate the majority of the chronotropic action of fentanyl involves vagal efferent impulses from the central nervous system.
选用6只杂种狗研究芬太尼诱发心动过缓的作用机制。在酸碱平衡和体温得到控制的情况下，于1.0%至1.2%的呼气末氟烷麻醉下，每隔1小时依次静脉注射5微克/千克枸橼酸芬太尼，并记录心率（HR）60分钟。两次注射后均出现与剂量相关的心率抑制。一周后，对相同的狗进行类似研究，只是在给予芬太尼之前先进行双侧颈迷走神经切断术。心率降低最多为有神经支配的狗所观察到的心率降低的10%。血清芬太尼水平相当。数据表明，芬太尼的变时作用主要涉及来自中枢神经系统的迷走传出冲动。
