犬在笑气-芬太尼和笑气-硫喷妥钠麻醉期间摄氧量与心血管动力学的相关性

Correlation of oxygen uptake and cardiovascular dynamics during N2O-fentanyl and N2O-thiopental anesthesia in the dog.

作者信息

Westenskow D R, Jordan W S, Hodges M R, Stanley T H

出版信息

Anesth Analg. 1978 Jan-Feb;57(1):37-41. doi: 10.1213/00000539-197801000-00008.

DOI:10.1213/00000539-197801000-00008

Abstract

The relationship between changes in wholebody O2 consumption (VO2) and cardiovascular dynamics during changing levels of N2O-fentanyl and N2O-thiopental anesthesia was determined in 24 dogs. Dose-dependent reductions in VO2, mean blood pressure, and cardiac output occurred with infusion of fentanyl and thiopental. Painful stimuli increased VO2 during light anesthesia but not during deeper levels of anesthesia. Deep levels of N2O-fentanyl and N2O-thiopental anesthesia may protect the patient with limited cardiac reserve by reducing VO2 and preventing increases in VO2 caused by painful stimuli.

摘要

在24只犬中确定了在N2O-芬太尼和N2O-硫喷妥钠麻醉水平变化期间，全身氧耗（VO2）变化与心血管动力学之间的关系。输注芬太尼和硫喷妥钠后，VO2、平均血压和心输出量呈剂量依赖性降低。在浅麻醉期间，疼痛刺激会增加VO2，但在深度麻醉时则不会。深度N2O-芬太尼和N2O-硫喷妥钠麻醉可能通过降低VO2并防止疼痛刺激引起的VO2增加来保护心脏储备有限的患者。