Gilbert P E, Martin W R
Drug Alcohol Depend. 1978 Mar;3(2):139-42. doi: 10.1016/0376-8716(78)90027-3.
The effects of thebaine were studied in nondependent and morphine-dependent chronic spinal dogs as well as in chronic spinal dogs receiving thebaine chronically. Thebaine did not produce any morphine-like effects in nondependent dogs nor did it precipitate an abstinence syndrome in morphine-dependent dogs. Large doses of naltrexone precipitated a mild abstinence syndrome in dogs receiving thebaine chronically; however, no withdrawal abstinence syndrome was observed after abrupt withdrawal. Thebaine is not a morphine-like drug, nor does it produce appreciable physical dependence in the dog.
在非依赖性和吗啡依赖性慢性脊髓犬以及长期接受蒂巴因的慢性脊髓犬中研究了蒂巴因的作用。蒂巴因在非依赖性犬中未产生任何吗啡样作用，在吗啡依赖性犬中也未引发戒断综合征。大剂量纳曲酮在长期接受蒂巴因的犬中引发了轻度戒断综合征；然而，突然停药后未观察到戒断综合征。蒂巴因不是吗啡样药物，在犬中也不会产生明显的身体依赖性。
